Valproic acid overdose: A case report and review of therapy

Bruce L. Houghton; James B. Bowers

Valproic acid overdose: A case report and review of therapy

Bruce L. Houghton, James B. Bowers

Department of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Valproic acid (VPA) is available as an antiepileptic therapy and has been used to treat bipolar disorder and migraine headaches. Reports to poison centers of VPA exposures have increased over the last few years, and there have been concerns about delayed toxicity after an overdose of VPA. We report a case of a woman with acute overdose of VPA who developed many of the complications commonly associated with the medication and review the current options available for treatment. There are many clinical manifestations of VPA overdose that are characteristic for the drug.

Original language	English (US)
Journal	MedGenMed Medscape General Medicine
Volume	5
Issue number	1
State	Published - Dec 1 2003

All Science Journal Classification (ASJC) codes

Medicine(all)

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AB - Valproic acid (VPA) is available as an antiepileptic therapy and has been used to treat bipolar disorder and migraine headaches. Reports to poison centers of VPA exposures have increased over the last few years, and there have been concerns about delayed toxicity after an overdose of VPA. We report a case of a woman with acute overdose of VPA who developed many of the complications commonly associated with the medication and review the current options available for treatment. There are many clinical manifestations of VPA overdose that are characteristic for the drug.

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