Variable gastrointestinal and urologic cancers in a lynch syndrome II kindred

Henry T. Lynch, J. David Richardson, Mohammad Amin, Jane F. Lynch, R. Jennifer Cavalieri, Earlene Bronson, Ramon M. Fusaro

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

There are no premonitory physical signs or biomarkers which can identify the genotypic status in Lynch syndrome II. Diagnosis is therefore dependent on the pedigree, with attention to cancer of all anatomic sites, inclusive of those cardinal features of its natural history. The tumor spectrum in Lynch syndrome II has continued to expand commensurately with increasing interest in this disorder. We report a family showing the constant cancer features of this syndrome but, in addition, occurrences of carcinoma of the bile duct, urologic system, and extremely early-onset carcinoma of the pancreas, in patients in the direct genetic lineage who were considered to be candidates for having inherited the deleterious genotype. Diagnosis of Lynch syndrome II is crucial in targeting its surveillance and management.

Original languageEnglish (US)
Pages (from-to)891-895
Number of pages5
JournalDiseases of the Colon & Rectum
Volume34
Issue number10
DOIs
StatePublished - Oct 1991

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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