Variations in chemotaxis and chemokinesis of neutrophils of different densities from patients with allergic rhinitis

H. Miyagawa, C. Okada, H. Sugiyama, R. J. Hopp, D. K. Agrawal, A. K. Bewtra, R. G. Townley

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Abstract

We investigated chemotaxis and chemokinesis of neutrophils of different densities from normals and subjects with allergic rhinitis (AR). The chemotaxis of neutrophils with lower density was significantly increased compared with neutrophils with higher density in AR using fMLP (P <.01) or PAF (P <.05). In normal subjects, however, there was no significant difference in neutrophil chemotaxis of the two fractions. No significant difference was found in neutrophil chemokinesis of the two fractions from AR or normals. These results indicate that neutrophils with lower density from AR possess greater affinity to fMLP or PAF as compared with neutrophils with higher density and this may be relevant to the pathophysiology of AR.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalAnnals of allergy
Volume67
Issue number5
StatePublished - Jan 1 1991

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Miyagawa, H., Okada, C., Sugiyama, H., Hopp, R. J., Agrawal, D. K., Bewtra, A. K., & Townley, R. G. (1991). Variations in chemotaxis and chemokinesis of neutrophils of different densities from patients with allergic rhinitis. Annals of allergy, 67(5), 515-519.