TY - JOUR
T1 - Visceral angioedema
T2 - An under-recognized complication of angiotensin-converting enzyme inhibitors
AU - Mutnuri, Sangeeta
AU - Khan, Adnan
AU - Variyam, Easwaran P.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Cough and upper airway angioedema are well-recognized adverse reactions of angiotensinconverting enzyme inhibitor (ACEI) therapy. Visceral angioedema is an infrequent and often unrecognized complication of ACEI therapy. We describe a patient in whom the diagnosis was delayed for > 2 years. A 60-year-old woman with hypertension on treatment with enalapril presented with complaints of abdominal pain and diarrhea for 2 days. Physical examination was significant for diffuse abdominal tenderness and hypotension. Laboratory data were normal except for leukocytosis and elevated creatinine. Computed tomography (CT) of the abdomen showed diffuse small bowel wall thickening. ACEI-induced visceral angioedema was considered, enalapril was discontinued and supportive care was provided. Patient’s symptoms and CT appearance improved 48 and 72 hours, respectively, after stopping enalapril. She remained symptom-free 1 year after discharge.
AB - Cough and upper airway angioedema are well-recognized adverse reactions of angiotensinconverting enzyme inhibitor (ACEI) therapy. Visceral angioedema is an infrequent and often unrecognized complication of ACEI therapy. We describe a patient in whom the diagnosis was delayed for > 2 years. A 60-year-old woman with hypertension on treatment with enalapril presented with complaints of abdominal pain and diarrhea for 2 days. Physical examination was significant for diffuse abdominal tenderness and hypotension. Laboratory data were normal except for leukocytosis and elevated creatinine. Computed tomography (CT) of the abdomen showed diffuse small bowel wall thickening. ACEI-induced visceral angioedema was considered, enalapril was discontinued and supportive care was provided. Patient’s symptoms and CT appearance improved 48 and 72 hours, respectively, after stopping enalapril. She remained symptom-free 1 year after discharge.
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U2 - 10.1080/00325481.2015.1001305
DO - 10.1080/00325481.2015.1001305
M3 - Article
C2 - 25578409
AN - SCOPUS:84940981678
VL - 127
SP - 215
EP - 217
JO - Postgraduate Medicine
JF - Postgraduate Medicine
SN - 0032-5481
IS - 2
ER -