Vitamin D and falls — the dosage conundrum

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Falls are a major health problem in elderly individuals. Although intensive physical therapy and management of hazards in the home can reduce falls by 25%, long-term practicality limits their use. Interest in vitamin D as a medical therapy has led to many trials; however, results using daily oral doses of vitamin D have been inconsistent. In the past 5 years, studies on the effect of bolus doses of vitamin D have produced surprising results. Bolus doses of vitamin D, given annually (at a dose of 300,000 IU or 500,000 IU) or monthly (at a dose of 24,000 IU or 60,000 IU) — equivalent to approximate daily doses of 800 IU, 1400 IU and 2,000 IU — result in a significant increase in the number of falls and fractures associated with serum levels of 25-hydroxyvitamin D greater than 40–45 ng/ml (equivalent to 100–112 nmol/l). These unexpected results show increased falls and fractures are adverse events related to vitamin D administration. Until further safety data is available, bolus dosing or daily doses should not exceed 3,000 IU and serum levels of 25-hydroxyvitamin D should not exceed 40–45 ng/ml (equivalent to 100–112 nmol/l) in elderly individuals.

Original languageEnglish (US)
JournalNature Reviews Endocrinology
DOIs
StateAccepted/In press - Aug 5 2016

Fingerprint

Vitamin D
Safety Management
Serum
Safety
Health
Therapeutics
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Vitamin D and falls — the dosage conundrum. / Gallagher, John Christopher G.

In: Nature Reviews Endocrinology, 05.08.2016.

Research output: Contribution to journalArticle

@article{eccaa0cc36f645969ec38cdb989f1f8a,
title = "Vitamin D and falls — the dosage conundrum",
abstract = "Falls are a major health problem in elderly individuals. Although intensive physical therapy and management of hazards in the home can reduce falls by 25{\%}, long-term practicality limits their use. Interest in vitamin D as a medical therapy has led to many trials; however, results using daily oral doses of vitamin D have been inconsistent. In the past 5 years, studies on the effect of bolus doses of vitamin D have produced surprising results. Bolus doses of vitamin D, given annually (at a dose of 300,000 IU or 500,000 IU) or monthly (at a dose of 24,000 IU or 60,000 IU) — equivalent to approximate daily doses of 800 IU, 1400 IU and 2,000 IU — result in a significant increase in the number of falls and fractures associated with serum levels of 25-hydroxyvitamin D greater than 40–45 ng/ml (equivalent to 100–112 nmol/l). These unexpected results show increased falls and fractures are adverse events related to vitamin D administration. Until further safety data is available, bolus dosing or daily doses should not exceed 3,000 IU and serum levels of 25-hydroxyvitamin D should not exceed 40–45 ng/ml (equivalent to 100–112 nmol/l) in elderly individuals.",
author = "Gallagher, {John Christopher G.}",
year = "2016",
month = "8",
day = "5",
doi = "10.1038/nrendo.2016.123",
language = "English (US)",
journal = "Nature Reviews Endocrinology",
issn = "1759-5029",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Vitamin D and falls — the dosage conundrum

AU - Gallagher, John Christopher G.

PY - 2016/8/5

Y1 - 2016/8/5

N2 - Falls are a major health problem in elderly individuals. Although intensive physical therapy and management of hazards in the home can reduce falls by 25%, long-term practicality limits their use. Interest in vitamin D as a medical therapy has led to many trials; however, results using daily oral doses of vitamin D have been inconsistent. In the past 5 years, studies on the effect of bolus doses of vitamin D have produced surprising results. Bolus doses of vitamin D, given annually (at a dose of 300,000 IU or 500,000 IU) or monthly (at a dose of 24,000 IU or 60,000 IU) — equivalent to approximate daily doses of 800 IU, 1400 IU and 2,000 IU — result in a significant increase in the number of falls and fractures associated with serum levels of 25-hydroxyvitamin D greater than 40–45 ng/ml (equivalent to 100–112 nmol/l). These unexpected results show increased falls and fractures are adverse events related to vitamin D administration. Until further safety data is available, bolus dosing or daily doses should not exceed 3,000 IU and serum levels of 25-hydroxyvitamin D should not exceed 40–45 ng/ml (equivalent to 100–112 nmol/l) in elderly individuals.

AB - Falls are a major health problem in elderly individuals. Although intensive physical therapy and management of hazards in the home can reduce falls by 25%, long-term practicality limits their use. Interest in vitamin D as a medical therapy has led to many trials; however, results using daily oral doses of vitamin D have been inconsistent. In the past 5 years, studies on the effect of bolus doses of vitamin D have produced surprising results. Bolus doses of vitamin D, given annually (at a dose of 300,000 IU or 500,000 IU) or monthly (at a dose of 24,000 IU or 60,000 IU) — equivalent to approximate daily doses of 800 IU, 1400 IU and 2,000 IU — result in a significant increase in the number of falls and fractures associated with serum levels of 25-hydroxyvitamin D greater than 40–45 ng/ml (equivalent to 100–112 nmol/l). These unexpected results show increased falls and fractures are adverse events related to vitamin D administration. Until further safety data is available, bolus dosing or daily doses should not exceed 3,000 IU and serum levels of 25-hydroxyvitamin D should not exceed 40–45 ng/ml (equivalent to 100–112 nmol/l) in elderly individuals.

UR - http://www.scopus.com/inward/record.url?scp=84982965500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982965500&partnerID=8YFLogxK

U2 - 10.1038/nrendo.2016.123

DO - 10.1038/nrendo.2016.123

M3 - Article

JO - Nature Reviews Endocrinology

JF - Nature Reviews Endocrinology

SN - 1759-5029

ER -