Vitamin D and its impact on maternal-fetal outcomes in pregnancy

A critical review

Shreya Agarwal, Oormila Kovilam, Devendra K. Agrawal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The role of vitamin D beyond its classical function in calcium homeostasis has been of significant interest in recent years. There has been expanding research on the pleiotropic role of vitamin D in pregnancy and the implications of its deficiency on maternal-fetal outcomes. Several studies have associated low maternal vitamin D status to adverse outcomes in pregnancy, including preeclampsia, gestational diabetes, preterm births, low birth weight, and others. Several randomized controlled clinical trials of Vitamin D supplementation during pregnancy have also been conducted. Though some of the studies found improvement in pregnancy outcomes with vitamin D supplementation, others have not shown any association. In this article, we have critically reviewed the observational and interventional studies, published primarily within the past two years (January 2014 to February 2016) on the influence of vitamin D deficiency on pregnancy and the impact of its supplementation. The potential underlying mechanisms of vitamin D in regulating each of the outcomes have also been discussed.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalCritical Reviews in Food Science and Nutrition
DOIs
StateAccepted/In press - Jun 15 2017

Fingerprint

pregnancy outcome
Vitamins
Pregnancy Outcome
vitamin D
Vitamin D
Mothers
pregnancy
Pregnancy
gestational diabetes
pre-eclampsia
premature birth
vitamin D deficiency
Vitamin D Deficiency
randomized clinical trials
Gestational Diabetes
low birth weight
Premature Birth
Low Birth Weight Infant
Pre-Eclampsia
Observational Studies

All Science Journal Classification (ASJC) codes

  • Food Science
  • Industrial and Manufacturing Engineering

Cite this

Vitamin D and its impact on maternal-fetal outcomes in pregnancy : A critical review. / Agarwal, Shreya; Kovilam, Oormila; Agrawal, Devendra K.

In: Critical Reviews in Food Science and Nutrition, 15.06.2017, p. 1-15.

Research output: Contribution to journalArticle

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