Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Jean Claude Souberbielle, Jean Jacques Body, Joan M. Lappe, Mario Plebani, Yehuda Shoenfeld, Thomas J. Wang, Heike A. Bischoff-Ferrari, Etienne Cavalier, Peter R. Ebeling, Patrice Fardellone, Sara Gandini, Damien Gruson, Alain P. Guérin, Lene Heickendorff, Bruce W. Hollis, Sofia Ish-Shalom, Guillaume Jean, Philipp von Landenberg, Alvaro Largura, Tomas OlssonCharles Pierrot-Deseilligny, Stefan Pilz, Angela Tincani, Andre Valcour, Armin Zittermann

Research output: Contribution to journalReview article

384 Citations (Scopus)

Abstract

Background: There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases. An international expert panel formulated recommendations on vitamin D for clinical practice, taking into consideration the best evidence available based on published literature today. In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations. Methods: Twenty-five experts from various disciplines (classical clinical applications, cardiology, autoimmunity, and cancer) established draft recommendations during a 2-day meeting. Thereafter, representatives of all disciplines refined the recommendations and related texts, subsequently reviewed by all panelists. For all recommendations, panelists expressed the extent of agreement using a 5-point scale. Results and conclusion: Recommendations were restricted to clinical practice and concern adult patients with or at risk for fractures, falls, cardiovascular or autoimmune diseases, and cancer. The panel reached substantial agreement about the need for vitamin D supplementation in specific groups of patients in these clinical areas and the need for assessing their 25-hydroxyvitamin D (25(OH)D) serum levels for optimal clinical care.A target range of at least 30 to 40ng/mL was recommended. As response to treatment varies by environmental factors and starting levels of 25(OH)D, testing may be warranted after at least 3months of supplementation. An assay measuring both 25(OH)D2 and 25(OH)D3 is recommended. Dark-skinned or veiled individuals not exposed much to the sun, elderly and institutionalized individuals may be supplemented (800IU/day) without baseline testing.

Original languageEnglish
Pages (from-to)709-715
Number of pages7
JournalAutoimmunity Reviews
Volume9
Issue number11
DOIs
StatePublished - Sep 2010

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Autoimmunity
Vitamin D
Cardiovascular Diseases
Health
Neoplasms
Expert Testimony
Solar System
Cardiology
Autoimmune Diseases
Epidemiologic Studies
Clinical Trials
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer : Recommendations for clinical practice. / Souberbielle, Jean Claude; Body, Jean Jacques; Lappe, Joan M.; Plebani, Mario; Shoenfeld, Yehuda; Wang, Thomas J.; Bischoff-Ferrari, Heike A.; Cavalier, Etienne; Ebeling, Peter R.; Fardellone, Patrice; Gandini, Sara; Gruson, Damien; Guérin, Alain P.; Heickendorff, Lene; Hollis, Bruce W.; Ish-Shalom, Sofia; Jean, Guillaume; von Landenberg, Philipp; Largura, Alvaro; Olsson, Tomas; Pierrot-Deseilligny, Charles; Pilz, Stefan; Tincani, Angela; Valcour, Andre; Zittermann, Armin.

In: Autoimmunity Reviews, Vol. 9, No. 11, 09.2010, p. 709-715.

Research output: Contribution to journalReview article

Souberbielle, JC, Body, JJ, Lappe, JM, Plebani, M, Shoenfeld, Y, Wang, TJ, Bischoff-Ferrari, HA, Cavalier, E, Ebeling, PR, Fardellone, P, Gandini, S, Gruson, D, Guérin, AP, Heickendorff, L, Hollis, BW, Ish-Shalom, S, Jean, G, von Landenberg, P, Largura, A, Olsson, T, Pierrot-Deseilligny, C, Pilz, S, Tincani, A, Valcour, A & Zittermann, A 2010, 'Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice', Autoimmunity Reviews, vol. 9, no. 11, pp. 709-715. https://doi.org/10.1016/j.autrev.2010.06.009
Souberbielle, Jean Claude ; Body, Jean Jacques ; Lappe, Joan M. ; Plebani, Mario ; Shoenfeld, Yehuda ; Wang, Thomas J. ; Bischoff-Ferrari, Heike A. ; Cavalier, Etienne ; Ebeling, Peter R. ; Fardellone, Patrice ; Gandini, Sara ; Gruson, Damien ; Guérin, Alain P. ; Heickendorff, Lene ; Hollis, Bruce W. ; Ish-Shalom, Sofia ; Jean, Guillaume ; von Landenberg, Philipp ; Largura, Alvaro ; Olsson, Tomas ; Pierrot-Deseilligny, Charles ; Pilz, Stefan ; Tincani, Angela ; Valcour, Andre ; Zittermann, Armin. / Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer : Recommendations for clinical practice. In: Autoimmunity Reviews. 2010 ; Vol. 9, No. 11. pp. 709-715.
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abstract = "Background: There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases. An international expert panel formulated recommendations on vitamin D for clinical practice, taking into consideration the best evidence available based on published literature today. In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations. Methods: Twenty-five experts from various disciplines (classical clinical applications, cardiology, autoimmunity, and cancer) established draft recommendations during a 2-day meeting. Thereafter, representatives of all disciplines refined the recommendations and related texts, subsequently reviewed by all panelists. For all recommendations, panelists expressed the extent of agreement using a 5-point scale. Results and conclusion: Recommendations were restricted to clinical practice and concern adult patients with or at risk for fractures, falls, cardiovascular or autoimmune diseases, and cancer. The panel reached substantial agreement about the need for vitamin D supplementation in specific groups of patients in these clinical areas and the need for assessing their 25-hydroxyvitamin D (25(OH)D) serum levels for optimal clinical care.A target range of at least 30 to 40ng/mL was recommended. As response to treatment varies by environmental factors and starting levels of 25(OH)D, testing may be warranted after at least 3months of supplementation. An assay measuring both 25(OH)D2 and 25(OH)D3 is recommended. Dark-skinned or veiled individuals not exposed much to the sun, elderly and institutionalized individuals may be supplemented (800IU/day) without baseline testing.",
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AU - Souberbielle, Jean Claude

AU - Body, Jean Jacques

AU - Lappe, Joan M.

AU - Plebani, Mario

AU - Shoenfeld, Yehuda

AU - Wang, Thomas J.

AU - Bischoff-Ferrari, Heike A.

AU - Cavalier, Etienne

AU - Ebeling, Peter R.

AU - Fardellone, Patrice

AU - Gandini, Sara

AU - Gruson, Damien

AU - Guérin, Alain P.

AU - Heickendorff, Lene

AU - Hollis, Bruce W.

AU - Ish-Shalom, Sofia

AU - Jean, Guillaume

AU - von Landenberg, Philipp

AU - Largura, Alvaro

AU - Olsson, Tomas

AU - Pierrot-Deseilligny, Charles

AU - Pilz, Stefan

AU - Tincani, Angela

AU - Valcour, Andre

AU - Zittermann, Armin

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N2 - Background: There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases. An international expert panel formulated recommendations on vitamin D for clinical practice, taking into consideration the best evidence available based on published literature today. In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations. Methods: Twenty-five experts from various disciplines (classical clinical applications, cardiology, autoimmunity, and cancer) established draft recommendations during a 2-day meeting. Thereafter, representatives of all disciplines refined the recommendations and related texts, subsequently reviewed by all panelists. For all recommendations, panelists expressed the extent of agreement using a 5-point scale. Results and conclusion: Recommendations were restricted to clinical practice and concern adult patients with or at risk for fractures, falls, cardiovascular or autoimmune diseases, and cancer. The panel reached substantial agreement about the need for vitamin D supplementation in specific groups of patients in these clinical areas and the need for assessing their 25-hydroxyvitamin D (25(OH)D) serum levels for optimal clinical care.A target range of at least 30 to 40ng/mL was recommended. As response to treatment varies by environmental factors and starting levels of 25(OH)D, testing may be warranted after at least 3months of supplementation. An assay measuring both 25(OH)D2 and 25(OH)D3 is recommended. Dark-skinned or veiled individuals not exposed much to the sun, elderly and institutionalized individuals may be supplemented (800IU/day) without baseline testing.

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