Abstract
The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).
| Original language | English (US) |
|---|---|
| Pages (from-to) | S178-S181 |
| Journal | Nutrition Reviews |
| Volume | 66 |
| Issue number | SUPPL.2 |
| DOIs | |
| State | Published - Oct 1 2008 |
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Nutrition and Dietetics
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Cite this
Heaney, R. P. (2008). Vitamin D: Criteria for safety and efficacy. Nutrition Reviews, 66(SUPPL.2), S178-S181. https://doi.org/10.1111/j.1753-4887.2008.00102.x