Vitamin D: Criteria for safety and efficacy

Robert P. Heaney

Research output: Contribution to journal › Article

97 Citations (Scopus)

Abstract

The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).

Original languageEnglish
JournalNutrition Reviews
Volume66
Issue numberSUPPL.2
DOIs
StatePublished - Oct 2008

Fingerprint

Cholecalciferol
Vitamin D
Safety
Food
Skin
Health
Serum
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Vitamin D : Criteria for safety and efficacy. / Heaney, Robert P.

In: Nutrition Reviews, Vol. 66, No. SUPPL.2, 10.2008.

Research output: Contribution to journal › Article

Heaney, RP 2008, 'Vitamin D: Criteria for safety and efficacy', Nutrition Reviews, vol. 66, no. SUPPL.2. https://doi.org/10.1111/j.1753-4887.2008.00102.x
Heaney RP. Vitamin D: Criteria for safety and efficacy. Nutrition Reviews. 2008 Oct;66(SUPPL.2). https://doi.org/10.1111/j.1753-4887.2008.00102.x
Heaney, Robert P. / Vitamin D : Criteria for safety and efficacy. In: Nutrition Reviews. 2008 ; Vol. 66, No. SUPPL.2.
@article{def1a3751aa9476d8f62d63e38467153,
title = "Vitamin D: Criteria for safety and efficacy",
abstract = "The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).",
author = "Heaney, {Robert P.}",
year = "2008",
month = "10",
doi = "10.1111/j.1753-4887.2008.00102.x",
language = "English",
volume = "66",
journal = "Nutrition Reviews",
issn = "0029-6643",
publisher = "Wiley-Blackwell",
number = "SUPPL.2",

}

TY - JOUR

T1 - Vitamin D

T2 - Criteria for safety and efficacy

AU - Heaney, Robert P.

PY - 2008/10

Y1 - 2008/10

N2 - The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).

AB - The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).

UR - http://www.scopus.com/inward/record.url?scp=52649117000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52649117000&partnerID=8YFLogxK

U2 - 10.1111/j.1753-4887.2008.00102.x

DO - 10.1111/j.1753-4887.2008.00102.x

M3 - Article

C2 - 18844846

AN - SCOPUS:52649117000

VL - 66

JO - Nutrition Reviews

JF - Nutrition Reviews

SN - 0029-6643

IS - SUPPL.2

ER -

Access to Document