Vitamin D: Criteria for safety and efficacy

Robert P. Heaney

doi:10.1111/j.1753-4887.2008.00102.x

Vitamin D: Criteria for safety and efficacy

Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).

Original language	English (US)
Pages (from-to)	S178-S181
Journal	Nutrition Reviews
Volume	66
Issue number	SUPPL.2
DOIs	https://doi.org/10.1111/j.1753-4887.2008.00102.x
State	Published - Oct 1 2008

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Nutrition and Dietetics

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