Vitamin D

Criteria for safety and efficacy

Robert P. Heaney

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).

Original languageEnglish
JournalNutrition Reviews
Volume66
Issue numberSUPPL.2
DOIs
StatePublished - Oct 2008

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Cholecalciferol
Vitamin D
Safety
Food
Skin
Health
Serum
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Vitamin D : Criteria for safety and efficacy. / Heaney, Robert P.

In: Nutrition Reviews, Vol. 66, No. SUPPL.2, 10.2008.

Research output: Contribution to journalArticle

Heaney, Robert P. / Vitamin D : Criteria for safety and efficacy. In: Nutrition Reviews. 2008 ; Vol. 66, No. SUPPL.2.
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