Abstract
Objective: The aim of this study was to test a hypothesized positive association between low vitamin D (VitD) serum levels and the severity of periodontal disease in women with HIV infection. Study Design: This was a cross-sectional secondary analysis of data from an oral substudy conducted within the Chicago site of the Women's Interagency HIV Study. Serum VitD levels and clinical attachment loss (CAL) measurements were available for 74 women with HIV infection. VitD levels were treated as both continuous and categorical variables in bivariate and multivariate analyses. Mean clinical attachment loss (mCAL) was determined for each subject by obtaining the averages of measurements taken at 4 sites in each measured tooth. Results: Average age of study participants (n = 74) was 39.6 years (standard deviation 7.2), and the majority were African Americans (70.3%) with VitD deficiency (58.1%). VitD deficiency was positively associated with higher mCAL (P =.012). After adjustment for race, age, smoking, and HIV viral load, an association was found between VitD deficiency and mCAL (Beta 0.438; P =.036). Conclusions: We identified a previously unreported association between VitD deficiency and mCAL in women with HIV infection. Larger and more inclusive, multisite, longitudinal studies are warranted to investigate whether these findings can be generalized to all individuals with HIV infection in the current treatment era and to determine causality.
| Original language | English (US) |
|---|---|
| Journal | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Pathology and Forensic Medicine
- Dentistry (miscellaneous)
- Radiology Nuclear Medicine and imaging
Cite this
Vitamin D deficiency and periodontal clinical attachment loss in HIV-seropositive women : A secondary analysis conducted in the Women's Interagency HIV Study (WIHS). / Dragonas, Panagiotis; Kaste, Linda M.; Nunn, Martha E.; Gajendrareddy, Praveen K.; Weber, Kathleen M.; Cohen, Mardge; Adeyemi, Oluwatoyin M.; French, Audrey L.; Sroussi, Herve Y.
In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin D deficiency and periodontal clinical attachment loss in HIV-seropositive women
T2 - A secondary analysis conducted in the Women's Interagency HIV Study (WIHS)
AU - Dragonas, Panagiotis
AU - Kaste, Linda M.
AU - Nunn, Martha E.
AU - Gajendrareddy, Praveen K.
AU - Weber, Kathleen M.
AU - Cohen, Mardge
AU - Adeyemi, Oluwatoyin M.
AU - French, Audrey L.
AU - Sroussi, Herve Y.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objective: The aim of this study was to test a hypothesized positive association between low vitamin D (VitD) serum levels and the severity of periodontal disease in women with HIV infection. Study Design: This was a cross-sectional secondary analysis of data from an oral substudy conducted within the Chicago site of the Women's Interagency HIV Study. Serum VitD levels and clinical attachment loss (CAL) measurements were available for 74 women with HIV infection. VitD levels were treated as both continuous and categorical variables in bivariate and multivariate analyses. Mean clinical attachment loss (mCAL) was determined for each subject by obtaining the averages of measurements taken at 4 sites in each measured tooth. Results: Average age of study participants (n = 74) was 39.6 years (standard deviation 7.2), and the majority were African Americans (70.3%) with VitD deficiency (58.1%). VitD deficiency was positively associated with higher mCAL (P =.012). After adjustment for race, age, smoking, and HIV viral load, an association was found between VitD deficiency and mCAL (Beta 0.438; P =.036). Conclusions: We identified a previously unreported association between VitD deficiency and mCAL in women with HIV infection. Larger and more inclusive, multisite, longitudinal studies are warranted to investigate whether these findings can be generalized to all individuals with HIV infection in the current treatment era and to determine causality.
AB - Objective: The aim of this study was to test a hypothesized positive association between low vitamin D (VitD) serum levels and the severity of periodontal disease in women with HIV infection. Study Design: This was a cross-sectional secondary analysis of data from an oral substudy conducted within the Chicago site of the Women's Interagency HIV Study. Serum VitD levels and clinical attachment loss (CAL) measurements were available for 74 women with HIV infection. VitD levels were treated as both continuous and categorical variables in bivariate and multivariate analyses. Mean clinical attachment loss (mCAL) was determined for each subject by obtaining the averages of measurements taken at 4 sites in each measured tooth. Results: Average age of study participants (n = 74) was 39.6 years (standard deviation 7.2), and the majority were African Americans (70.3%) with VitD deficiency (58.1%). VitD deficiency was positively associated with higher mCAL (P =.012). After adjustment for race, age, smoking, and HIV viral load, an association was found between VitD deficiency and mCAL (Beta 0.438; P =.036). Conclusions: We identified a previously unreported association between VitD deficiency and mCAL in women with HIV infection. Larger and more inclusive, multisite, longitudinal studies are warranted to investigate whether these findings can be generalized to all individuals with HIV infection in the current treatment era and to determine causality.
UR - http://www.scopus.com/inward/record.url?scp=85043764939&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043764939&partnerID=8YFLogxK
U2 - 10.1016/j.oooo.2018.02.006
DO - 10.1016/j.oooo.2018.02.006
M3 - Article
C2 - 29550079
AN - SCOPUS:85043764939
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
SN - 2212-4403
ER -