Vitamin D

Do we get enough?: A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe

E. M. Brouwer-Brolsma, H. A. Bischoff-Ferrari, R. Bouillon, E. J M Feskens, John Christopher G. Gallagher, E. Hypponen, D. J. Llewellyn, E. Stoecklin, J. Dierkes, A. K. Kies, F. J. Kok, C. Lamberg-Allardt, U. Moser, S. Pilz, W. H. Saris, N. M. Van Schoor, P. Weber, R. Witkamp, A. Zittermann, L. C P G M De Groot

Research output: Contribution to journalReview article

78 Citations (Scopus)

Abstract

On September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized. Introduction: Several groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive. Methods: To exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled "Vitamin D Expert Meeting: Do we get enough?", was organized. Results: Despite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population. Conclusion: To reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.

Original languageEnglish
Pages (from-to)1567-1577
Number of pages11
JournalOsteoporosis International
Volume24
Issue number5
DOIs
StatePublished - May 2013

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Recommended Dietary Allowances
Vitamin D
Health
Bone and Bones
Cardiovascular System
Serum
Population
Observational Studies
Pancreas
Immune System
Randomized Controlled Trials
Maintenance

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Vitamin D : Do we get enough?: A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. / Brouwer-Brolsma, E. M.; Bischoff-Ferrari, H. A.; Bouillon, R.; Feskens, E. J M; Gallagher, John Christopher G.; Hypponen, E.; Llewellyn, D. J.; Stoecklin, E.; Dierkes, J.; Kies, A. K.; Kok, F. J.; Lamberg-Allardt, C.; Moser, U.; Pilz, S.; Saris, W. H.; Van Schoor, N. M.; Weber, P.; Witkamp, R.; Zittermann, A.; De Groot, L. C P G M.

In: Osteoporosis International, Vol. 24, No. 5, 05.2013, p. 1567-1577.

Research output: Contribution to journalReview article

Brouwer-Brolsma, EM, Bischoff-Ferrari, HA, Bouillon, R, Feskens, EJM, Gallagher, JCG, Hypponen, E, Llewellyn, DJ, Stoecklin, E, Dierkes, J, Kies, AK, Kok, FJ, Lamberg-Allardt, C, Moser, U, Pilz, S, Saris, WH, Van Schoor, NM, Weber, P, Witkamp, R, Zittermann, A & De Groot, LCPGM 2013, 'Vitamin D: Do we get enough?: A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe', Osteoporosis International, vol. 24, no. 5, pp. 1567-1577. https://doi.org/10.1007/s00198-012-2231-3
Brouwer-Brolsma, E. M. ; Bischoff-Ferrari, H. A. ; Bouillon, R. ; Feskens, E. J M ; Gallagher, John Christopher G. ; Hypponen, E. ; Llewellyn, D. J. ; Stoecklin, E. ; Dierkes, J. ; Kies, A. K. ; Kok, F. J. ; Lamberg-Allardt, C. ; Moser, U. ; Pilz, S. ; Saris, W. H. ; Van Schoor, N. M. ; Weber, P. ; Witkamp, R. ; Zittermann, A. ; De Groot, L. C P G M. / Vitamin D : Do we get enough?: A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. In: Osteoporosis International. 2013 ; Vol. 24, No. 5. pp. 1567-1577.
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AU - Bischoff-Ferrari, H. A.

AU - Bouillon, R.

AU - Feskens, E. J M

AU - Gallagher, John Christopher G.

AU - Hypponen, E.

AU - Llewellyn, D. J.

AU - Stoecklin, E.

AU - Dierkes, J.

AU - Kies, A. K.

AU - Kok, F. J.

AU - Lamberg-Allardt, C.

AU - Moser, U.

AU - Pilz, S.

AU - Saris, W. H.

AU - Van Schoor, N. M.

AU - Weber, P.

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AU - Zittermann, A.

AU - De Groot, L. C P G M

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N2 - On September 29, 2011, acknowledged experts in the field of vitamin D, mainly European, were brought together in order to discuss the recent scientific advances in relation to vitamin D: the current requirements and associations with various health outcomes. In this article, the discussions resulting from the meeting are summarized. Introduction: Several groups at risk for developing vitamin D insufficiency have been identified. Accordingly, reviews indicate that a significant percentage of the population worldwide have serum 25-hydroxyvitamin D levels below 50 nmol/l. In addition to the role of vitamin D in bone health, recent studies suggest that it may play a pivotal role in other systems, e.g., the cardiovascular system, pancreas, muscle, immune system and brain. Most evidence, however, is obtained from observational studies and yet inconclusive. Methods: To exchange and broaden knowledge on the requirements for vitamin D and its effect on various health outcomes, a workshop entitled "Vitamin D Expert Meeting: Do we get enough?", was organized. Results: Despite low vitamin D levels worldwide, consensus on the definition of deficiency is not yet reached. In order to define cut-off points for vitamin D whilst taking into account extraskeletal health effects, randomized controlled trials in these fields are warranted. The experts do emphasize that there is evidence to suggest an important role for vitamin D in the maintenance of optimal bone health at all ages and that vitamin D supplementation, in most studies co-administered with calcium, reduces fracture risk in the senior population. Conclusion: To reach a serum 25-hydroxyvitamin D level of 50 nmol/l older adults aged ≥65 years are therefore recommended to meet a mean daily vitamin D intake of 20 μg (800 IU), which is best achieved with a supplement.

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