Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis

Shannon K. Quirk, Ellecia Rainwater, Anna K. Shure, Devendra K. Agrawal

    Research output: Contribution to journalReview articlepeer-review

    14 Scopus citations

    Abstract

    ABSTRACT: Vitamin D influences allergen-induced pathways in the innate and adaptive immune system, and its potential immunomodulatory role in allergic skin disorders has been explored. This comprehensive review article provides an overview of the role of vitamin D in three common dermatologic conditions: atopic dermatitis (AD), chronic urticaria, and allergic contact dermatitis (ACD). Whereas the literature regarding vitamin D and AD has resulted in mixed findings, several studies have described an inverse relationship between vitamin D levels and AD severity, and improvement in AD with vitamin D supplementation. Similarly, several studies report an inverse relationship between vitamin D levels and severity of chronic urticaria. Although current research in humans remains limited, an increased likelihood of ACD has been demonstrated in vitamin D-deficient mice. Additional well-designed clinical trials will be necessary to determine whether vitamin D supplementation should be recommended for prevention or adjuvant treatment of these common dermatologic conditions.

    Original languageEnglish
    Pages (from-to)839-847
    Number of pages9
    JournalExpert Review of Clinical Immunology
    Volume12
    Issue number8
    DOIs
    StatePublished - Aug 2 2016

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Fingerprint

    Dive into the research topics of 'Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis'. Together they form a unique fingerprint.

    Cite this