Vitamin D metabolism and therapy of osteoporosis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pathophysiological changes in vitamin D metabolism lead to hypovitaminosis (osteomalacia) and/or osteoporosis with old age and require a corresponding differential therapy. For patients with hypovitaminosis, i.e. patients with low 25-hydroxyvitamin D3 levels, a treatment with 400-800 I.E. vitamin D per day is the first choice. Subclinical or clinical osteomalacia can also be involved in the development of senile osteoporoses in patients who are more than 80 years of age, particularly in old people's homes. In principle, a distinction between hypovitaminosis and osteoporoses is necessary. There is no evidence that a treatment with low doses of vitamin D contributes significantly to a decrease in the fracture rate of patients suffering from osteoporosis who have normal substrate 25-hydroxyvitamin D levels. However, nearly all large preventive studies on osteoporosis using active vitamin D derivates revealed a significant decrease in the fracture rate while showing a rather low toxicity. The incidence of hypercalcaemia is

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalAktuelle Rheumatologie
Volume19
Issue numberSUPPL. 1
StatePublished - 1994

Fingerprint

Vitamin D
Osteoporosis
Osteomalacia
Therapeutics
Calcifediol
Hypercalcemia
Incidence

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Vitamin D metabolism and therapy of osteoporosis. / Gallagher, John Christopher G.

In: Aktuelle Rheumatologie, Vol. 19, No. SUPPL. 1, 1994, p. 31-34.

Research output: Contribution to journalArticle

@article{b390c5f6b8cd4b659a88ec4f60bf1aff,
title = "Vitamin D metabolism and therapy of osteoporosis",
abstract = "Pathophysiological changes in vitamin D metabolism lead to hypovitaminosis (osteomalacia) and/or osteoporosis with old age and require a corresponding differential therapy. For patients with hypovitaminosis, i.e. patients with low 25-hydroxyvitamin D3 levels, a treatment with 400-800 I.E. vitamin D per day is the first choice. Subclinical or clinical osteomalacia can also be involved in the development of senile osteoporoses in patients who are more than 80 years of age, particularly in old people's homes. In principle, a distinction between hypovitaminosis and osteoporoses is necessary. There is no evidence that a treatment with low doses of vitamin D contributes significantly to a decrease in the fracture rate of patients suffering from osteoporosis who have normal substrate 25-hydroxyvitamin D levels. However, nearly all large preventive studies on osteoporosis using active vitamin D derivates revealed a significant decrease in the fracture rate while showing a rather low toxicity. The incidence of hypercalcaemia is",
author = "Gallagher, {John Christopher G.}",
year = "1994",
language = "English",
volume = "19",
pages = "31--34",
journal = "Aktuelle Rheumatologie",
issn = "0341-051X",
publisher = "Georg Thieme Verlag",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Vitamin D metabolism and therapy of osteoporosis

AU - Gallagher, John Christopher G.

PY - 1994

Y1 - 1994

N2 - Pathophysiological changes in vitamin D metabolism lead to hypovitaminosis (osteomalacia) and/or osteoporosis with old age and require a corresponding differential therapy. For patients with hypovitaminosis, i.e. patients with low 25-hydroxyvitamin D3 levels, a treatment with 400-800 I.E. vitamin D per day is the first choice. Subclinical or clinical osteomalacia can also be involved in the development of senile osteoporoses in patients who are more than 80 years of age, particularly in old people's homes. In principle, a distinction between hypovitaminosis and osteoporoses is necessary. There is no evidence that a treatment with low doses of vitamin D contributes significantly to a decrease in the fracture rate of patients suffering from osteoporosis who have normal substrate 25-hydroxyvitamin D levels. However, nearly all large preventive studies on osteoporosis using active vitamin D derivates revealed a significant decrease in the fracture rate while showing a rather low toxicity. The incidence of hypercalcaemia is

AB - Pathophysiological changes in vitamin D metabolism lead to hypovitaminosis (osteomalacia) and/or osteoporosis with old age and require a corresponding differential therapy. For patients with hypovitaminosis, i.e. patients with low 25-hydroxyvitamin D3 levels, a treatment with 400-800 I.E. vitamin D per day is the first choice. Subclinical or clinical osteomalacia can also be involved in the development of senile osteoporoses in patients who are more than 80 years of age, particularly in old people's homes. In principle, a distinction between hypovitaminosis and osteoporoses is necessary. There is no evidence that a treatment with low doses of vitamin D contributes significantly to a decrease in the fracture rate of patients suffering from osteoporosis who have normal substrate 25-hydroxyvitamin D levels. However, nearly all large preventive studies on osteoporosis using active vitamin D derivates revealed a significant decrease in the fracture rate while showing a rather low toxicity. The incidence of hypercalcaemia is

UR - http://www.scopus.com/inward/record.url?scp=0028149031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028149031&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028149031

VL - 19

SP - 31

EP - 34

JO - Aktuelle Rheumatologie

JF - Aktuelle Rheumatologie

SN - 0341-051X

IS - SUPPL. 1

ER -