Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine

Ryan M. Trowbridge, Mario V. Mitkov, William J. Hunter, Devendra K. Agrawal

Research output: Contribution to journalArticle

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Abstract

The immunomodulatory role of vitamin D in many diseases is well established. However, the relationship between vitamin D status and skin cancers is unclear. In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melanoma skin cancers, our findings suggest a potential role of vitamin D-deficiency in the progression of skin malignancies.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalExperimental and Molecular Pathology
Volume96
Issue number1
DOIs
StatePublished - Feb 2014

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Calcitriol Receptors
Vitamin D
Skin
Skin Neoplasms
Swine
Vitamin D Deficiency
Epidermis
Melanoma
Neoplasms
Staining and Labeling
Proteins

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

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Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine. / Trowbridge, Ryan M.; Mitkov, Mario V.; Hunter, William J.; Agrawal, Devendra K.

In: Experimental and Molecular Pathology, Vol. 96, No. 1, 02.2014, p. 42-47.

Research output: Contribution to journalArticle

Trowbridge, Ryan M. ; Mitkov, Mario V. ; Hunter, William J. ; Agrawal, Devendra K. / Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine. In: Experimental and Molecular Pathology. 2014 ; Vol. 96, No. 1. pp. 42-47.
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