Vitamin D receptor expression and neoadjuvant therapy in esophageal adenocarcinoma

Ryan Trowbridge; Poonam K Sharma; William J. Hunter; Devendra K. Agrawal

doi:10.1016/j.yexmp.2012.04.018

Vitamin D receptor expression and neoadjuvant therapy in esophageal adenocarcinoma

Ryan Trowbridge, Poonam K Sharma, William J. Hunter, Devendra K. Agrawal

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20 Scopus citations

Abstract

Esophageal adenocarcinoma carries a poor prognosis. Tumor response to neoadjuvant therapy is a key prognostic factor in patients with adenocarcinoma of the esophagus, but is inconsistent. Identifying tumor characteristics that portend a favorable response to neoadjuvant therapy would be a valuable clinical tool. The anticancer actions of vitamin D and its receptor may have implications. In this study, 15 biopsy specimens were procured retrospectively from patients being treated for adenocarcinoma of the esophagus. The tissue was immunostained for the vitamin D receptor and compared on the basis of response to neoadjuvant therapy. Tumors that did not respond to neoadjuvant therapy had greater expression of VDR than tumors that responded completely. Expression of VDR declined with tumor de-differentiation. The data suggest that a relationship between vitamin D receptor expression and response to neoadjuvant therapy is plausible.

Original language	English
Pages (from-to)	147-153
Number of pages	7
Journal	Experimental and Molecular Pathology
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/j.yexmp.2012.04.018
Publication status	Published - Aug 2012

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All Science Journal Classification (ASJC) codes

Clinical Biochemistry
Molecular Biology
Pathology and Forensic Medicine

Cite this

Trowbridge, R., Sharma, P. K., Hunter, W. J., & Agrawal, D. K. (2012). Vitamin D receptor expression and neoadjuvant therapy in esophageal adenocarcinoma. Experimental and Molecular Pathology, 93(1), 147-153. https://doi.org/10.1016/j.yexmp.2012.04.018

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10.1016/j.yexmp.2012.04.018