Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density

M. J. Barger-Lux, R. P. Heaney, J. Hayes, H. F. DeLuca, M. L. Johnson, G. Gong

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

We determined vitamin D receptor (VDR) gene alleles (based on the BsmI restriction site polymorphism), duodenal mucosal receptor density, bone mass at spine and total body, and body size in 32 healthy premenopausal females. While we found no relationship between allele and receptor density in duodenal mucosa, bone mineral content (BMC) at both spine and total body was significantly associated with VDR gene alleles. BMC was highest for the bb allele, lowest for BB, and intermediate for Bb. A similar association was noted between allele and body size variables, particularly weight. When BMC was adjusted for body weight, the association with VDR polymorphism disappeared. The VDR gene polymorphism may be affecting bone mass not through classical nutritional mechanisms (e.g., intestinal calcium absorption), but through an influence on body size.

Original languageEnglish (US)
Pages (from-to)161-162
Number of pages2
JournalCalcified Tissue International
Volume57
Issue number2
DOIs
StatePublished - Aug 1 1995

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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    Barger-Lux, M. J., Heaney, R. P., Hayes, J., DeLuca, H. F., Johnson, M. L., & Gong, G. (1995). Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density. Calcified Tissue International, 57(2), 161-162. https://doi.org/10.1007/BF00298438