Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions

Shih-Chuan Cheng; Alyssa A. Goetzinger; John N. Mordeson

Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions

Shih-Chuan Cheng, Alyssa A. Goetzinger, John N. Mordeson

Department of Mathematics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.

Original language	English
Title of host publication	Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002
Editors	J.H. Caulfield, S.H. Chen, H.D. Cheng, R. Duro, J.H. Caufield, S.H. Chen, H.D. Cheng, R. Duro, V. Honavar
Pages	164-167
Number of pages	4
Volume	6
Publication status	Published - 2002
Event	Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002 - Research Triange Park, NC, United States Duration: Mar 8 2002 → Mar 13 2002

Other

Other	Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002
Country	United States
City	Research Triange Park, NC
Period	3/8/02 → 3/13/02

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All Science Journal Classification (ASJC) codes

Computer Science(all)

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Cheng, S-C., Goetzinger, A. A., & Mordeson, J. N. (2002). Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions. In J. H. Caulfield, S. H. Chen, H. D. Cheng, R. Duro, J. H. Caufield, S. H. Chen, H. D. Cheng, R. Duro, ... V. Honavar (Eds.), Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002 (Vol. 6, pp. 164-167)

Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density : Analysis by Use of Belief Functions. / Cheng, Shih-Chuan; Goetzinger, Alyssa A.; Mordeson, John N.

Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002. ed. / J.H. Caulfield; S.H. Chen; H.D. Cheng; R. Duro; J.H. Caufield; S.H. Chen; H.D. Cheng; R. Duro; V. Honavar. Vol. 6 2002. p. 164-167.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Cheng, S-C, Goetzinger, AA & Mordeson, JN 2002, Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions. in JH Caulfield, SH Chen, HD Cheng, R Duro, JH Caufield, SH Chen, HD Cheng, R Duro & V Honavar (eds), Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002. vol. 6, pp. 164-167, Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002, Research Triange Park, NC, United States, 3/8/02.

Cheng, Shih-Chuan ; Goetzinger, Alyssa A. ; Mordeson, John N. / Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density : Analysis by Use of Belief Functions. Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002. editor / J.H. Caulfield ; S.H. Chen ; H.D. Cheng ; R. Duro ; J.H. Caufield ; S.H. Chen ; H.D. Cheng ; R. Duro ; V. Honavar. Vol. 6 2002. pp. 164-167

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title = "Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions",

abstract = "A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.",

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N2 - A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.

AB - A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.

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ER -

Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions

Abstract

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