Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density

Analysis by Use of Belief Functions

Shih-Chuan Cheng, Alyssa A. Goetzinger, John N. Mordeson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.

Original languageEnglish
Title of host publicationProceedings of the 6th Joint Conference on Information Sciences, JCIS 2002
EditorsJ.H. Caulfield, S.H. Chen, H.D. Cheng, R. Duro, J.H. Caufield, S.H. Chen, H.D. Cheng, R. Duro, V. Honavar
Pages164-167
Number of pages4
Volume6
StatePublished - 2002
EventProceedings of the 6th Joint Conference on Information Sciences, JCIS 2002 - Research Triange Park, NC, United States
Duration: Mar 8 2002Mar 13 2002

Other

OtherProceedings of the 6th Joint Conference on Information Sciences, JCIS 2002
CountryUnited States
CityResearch Triange Park, NC
Period3/8/023/13/02

Fingerprint

Vitamins
Polymorphism
Bone
Minerals
Genes

All Science Journal Classification (ASJC) codes

  • Computer Science(all)

Cite this

Cheng, S-C., Goetzinger, A. A., & Mordeson, J. N. (2002). Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions. In J. H. Caulfield, S. H. Chen, H. D. Cheng, R. Duro, J. H. Caufield, S. H. Chen, H. D. Cheng, R. Duro, ... V. Honavar (Eds.), Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002 (Vol. 6, pp. 164-167)

Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density : Analysis by Use of Belief Functions. / Cheng, Shih-Chuan; Goetzinger, Alyssa A.; Mordeson, John N.

Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002. ed. / J.H. Caulfield; S.H. Chen; H.D. Cheng; R. Duro; J.H. Caufield; S.H. Chen; H.D. Cheng; R. Duro; V. Honavar. Vol. 6 2002. p. 164-167.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cheng, S-C, Goetzinger, AA & Mordeson, JN 2002, Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions. in JH Caulfield, SH Chen, HD Cheng, R Duro, JH Caufield, SH Chen, HD Cheng, R Duro & V Honavar (eds), Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002. vol. 6, pp. 164-167, Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002, Research Triange Park, NC, United States, 3/8/02.
Cheng S-C, Goetzinger AA, Mordeson JN. Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions. In Caulfield JH, Chen SH, Cheng HD, Duro R, Caufield JH, Chen SH, Cheng HD, Duro R, Honavar V, editors, Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002. Vol. 6. 2002. p. 164-167
Cheng, Shih-Chuan ; Goetzinger, Alyssa A. ; Mordeson, John N. / Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density : Analysis by Use of Belief Functions. Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002. editor / J.H. Caulfield ; S.H. Chen ; H.D. Cheng ; R. Duro ; J.H. Caufield ; S.H. Chen ; H.D. Cheng ; R. Duro ; V. Honavar. Vol. 6 2002. pp. 164-167
@inproceedings{2d0dc125efff4d12bc40c45697484917,
title = "Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions",
abstract = "A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.",
author = "Shih-Chuan Cheng and Goetzinger, {Alyssa A.} and Mordeson, {John N.}",
year = "2002",
language = "English",
isbn = "0970789017",
volume = "6",
pages = "164--167",
editor = "J.H. Caulfield and S.H. Chen and H.D. Cheng and R. Duro and J.H. Caufield and S.H. Chen and H.D. Cheng and R. Duro and V. Honavar",
booktitle = "Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002",

}

TY - GEN

T1 - Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density

T2 - Analysis by Use of Belief Functions

AU - Cheng, Shih-Chuan

AU - Goetzinger, Alyssa A.

AU - Mordeson, John N.

PY - 2002

Y1 - 2002

N2 - A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.

AB - A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.

UR - http://www.scopus.com/inward/record.url?scp=1642339625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642339625&partnerID=8YFLogxK

M3 - Conference contribution

SN - 0970789017

VL - 6

SP - 164

EP - 167

BT - Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002

A2 - Caulfield, J.H.

A2 - Chen, S.H.

A2 - Cheng, H.D.

A2 - Duro, R.

A2 - Caufield, J.H.

A2 - Chen, S.H.

A2 - Cheng, H.D.

A2 - Duro, R.

A2 - Honavar, V.

ER -