Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions

Shih Chuan Cheng, Alyssa A. Goetzinger, John N. Mordeson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A recent meta-analysis of 16 publications suggests that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP), p > 0.05, at all sites analyzed when false positive studies are excluded [7]. Although more papers are being published, results are still conflicting. We re-addressed this issue with an approach using two methods involving fuzzy mathematics, [4]. Fifty-five publications on spinal BMD were analyzed as were 73 publications on hip BMD. In this paper, an analysis by belief functions seems to confirm the findings of [4]. This analysis suggests that spinal BMD is associated with VDRGP in females before or after menopause. This BMD - VDR association is also evident in studies in populations males and females combined.

Original languageEnglish (US)
Title of host publicationProceedings of the 6th Joint Conference on Information Sciences, JCIS 2002
EditorsJ.H. Caulfield, S.H. Chen, H.D. Cheng, R. Duro, J.H. Caufield, S.H. Chen, H.D. Cheng, R. Duro, V. Honavar
Pages164-167
Number of pages4
StatePublished - Dec 1 2002
EventProceedings of the 6th Joint Conference on Information Sciences, JCIS 2002 - Research Triange Park, NC, United States
Duration: Mar 8 2002Mar 13 2002

Publication series

NameProceedings of the Joint Conference on Information Sciences
Volume6

Other

OtherProceedings of the 6th Joint Conference on Information Sciences, JCIS 2002
CountryUnited States
CityResearch Triange Park, NC
Period3/8/023/13/02

All Science Journal Classification (ASJC) codes

  • Computer Science(all)

Fingerprint Dive into the research topics of 'Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions'. Together they form a unique fingerprint.

  • Cite this

    Cheng, S. C., Goetzinger, A. A., & Mordeson, J. N. (2002). Vitamin D Receptor Gene Polymorphism's Effect on Bone Mineral Density: Analysis by Use of Belief Functions. In J. H. Caulfield, S. H. Chen, H. D. Cheng, R. Duro, J. H. Caufield, S. H. Chen, H. D. Cheng, R. Duro, & V. Honavar (Eds.), Proceedings of the 6th Joint Conference on Information Sciences, JCIS 2002 (pp. 164-167). (Proceedings of the Joint Conference on Information Sciences; Vol. 6).