Abstract
Background: Vitamin D mediates its action via Vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of Vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer. The association of VDR polymorphism with cancer has been reported; however, the literature lacks critical analyses of the studies in last 3 years. Materials and Methods: A systematic search of PubMed database (2015 through mid-2017) was conducted to provide a comprehensive overview of this clinical arena. Results: Studies on the association of VDR polymorphisms FokI, BsmI, TaqI, and ApaI and cancer have suggested the involvement of VDR polymorphism in tumorigenesis. Conclusion: The inconsistent results and lack of the studies in some cancer types warrant additional research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3991-4003 |
| Number of pages | 13 |
| Journal | Anticancer Research |
| Volume | 37 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2017 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Vitamin D receptor polymorphism and cancer : An update. / Rai, Vikrant; Abdo, Joe; Agrawal, Swati; Agrawal, Devendra K.
In: Anticancer Research, Vol. 37, No. 8, 01.08.2017, p. 3991-4003.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Vitamin D receptor polymorphism and cancer
T2 - An update
AU - Rai, Vikrant
AU - Abdo, Joe
AU - Agrawal, Swati
AU - Agrawal, Devendra K.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background: Vitamin D mediates its action via Vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of Vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer. The association of VDR polymorphism with cancer has been reported; however, the literature lacks critical analyses of the studies in last 3 years. Materials and Methods: A systematic search of PubMed database (2015 through mid-2017) was conducted to provide a comprehensive overview of this clinical arena. Results: Studies on the association of VDR polymorphisms FokI, BsmI, TaqI, and ApaI and cancer have suggested the involvement of VDR polymorphism in tumorigenesis. Conclusion: The inconsistent results and lack of the studies in some cancer types warrant additional research.
AB - Background: Vitamin D mediates its action via Vitamin D receptor (VDR) and is involved in a wide variety of biological processes including regulation of cell proliferation and differentiation in normal tissue and apoptosis, and cell adhesion in tumor cells. The study of genetic variations in VDR may elucidate the association of Vitamin D levels, its metabolism, and VDR polymorphism with various diseases and cancer. The association of VDR polymorphism with cancer has been reported; however, the literature lacks critical analyses of the studies in last 3 years. Materials and Methods: A systematic search of PubMed database (2015 through mid-2017) was conducted to provide a comprehensive overview of this clinical arena. Results: Studies on the association of VDR polymorphisms FokI, BsmI, TaqI, and ApaI and cancer have suggested the involvement of VDR polymorphism in tumorigenesis. Conclusion: The inconsistent results and lack of the studies in some cancer types warrant additional research.
UR - http://www.scopus.com/inward/record.url?scp=85026206886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026206886&partnerID=8YFLogxK
U2 - 10.21873/anticanres.11784
DO - 10.21873/anticanres.11784
M3 - Review article
C2 - 28739681
AN - SCOPUS:85026206886
VL - 37
SP - 3991
EP - 4003
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 8
ER -