Vitamin D Status and Associations With Risk Factors for Cardiovascular Disease and Diabetes in Children Enrolled in a Medical Weight Management Program

Corrine Hanson, Ann Anderson-Berry, Shelby Hoskins, Elizabeth Lyden, Laura Bilek, Tamara Dolphens, Krystal Hartmann, Mary Jane Hawkins, Cristina F. Fernández

Research output: Contribution to journalArticle

Abstract

Background. Studies of vitamin D status have linked low 25(OH)D levels with biomarkers of cardiovascular disease and diabetes. Obese children and adolescents are at greater risk of vitamin D deficiency as vitamin D is thought to be sequestered in adipose tissue. The objective of this analysis was to examine the associations between 25(OH)D status and risk factors for cardiovascular disease and diabetes in a population of overweight and obese children enrolled in a medical management program. Materials and Methods. A retrospective chart review was conducted of 161 children enrolled in a medical weight management program. Pearson correlation coefficient were used to evaluate associations of biochemical measurements and 25(OH)D status. Multiple regression was used to evaluate 25(OH)D levels as a predictor of risk factors for cardiovascular disease and diabetes. Results. The mean body mass index (BMI) of the population was 34 kg/m2, mean 25(OH)D levels were 21.8 ng/mL. White subjects had significantly higher 25(OH)D levels than non-whites (24.1 vs 19.2, P =.004). 25(OH)D levels were inversely related to BMI (r = −0.21, P =.03) and waist circumference (r = −0.23, P =.02). After adjustment for BMI and age, 25(OH)D was significantly associated with total cholesterol (P =.0003), triglycerides (P =.0007), homeostasis model assessment–estimated insulin resistance (HOMA-IR; P =.005) and insulin (P =.0003). The decrease in each unit of cholesterol, triglycerides, and insulin for each 1% increase in log transformed 25(OH)D were 0.3, 0.65, and 0.1,1 respectively. Each 1% increase in 25(OH)D levels was associated with a 0.05% decrease in HOMA-IR values. Conclusion. Vitamin D status was associated with risk factors for diabetes and cardiovascular disease in an obese pediatric population.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalInfant, Child, and Adolescent Nutrition
Volume6
Issue number4
DOIs
StatePublished - Aug 13 2014

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weight control programs
vitamin D
Vitamin D
cardiovascular diseases
diabetes
Cardiovascular Diseases
risk factors
body mass index
Weights and Measures
Body Mass Index
Triglycerides
insulin
triacylglycerols
Cholesterol
cholesterol
Insulin
Population
vitamin D deficiency
Vitamin D Deficiency
waist circumference

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics
  • Pediatrics, Perinatology, and Child Health

Cite this

Vitamin D Status and Associations With Risk Factors for Cardiovascular Disease and Diabetes in Children Enrolled in a Medical Weight Management Program. / Hanson, Corrine; Anderson-Berry, Ann; Hoskins, Shelby; Lyden, Elizabeth; Bilek, Laura; Dolphens, Tamara; Hartmann, Krystal; Hawkins, Mary Jane; Fernández, Cristina F.

In: Infant, Child, and Adolescent Nutrition, Vol. 6, No. 4, 13.08.2014, p. 233-239.

Research output: Contribution to journalArticle

Hanson, Corrine ; Anderson-Berry, Ann ; Hoskins, Shelby ; Lyden, Elizabeth ; Bilek, Laura ; Dolphens, Tamara ; Hartmann, Krystal ; Hawkins, Mary Jane ; Fernández, Cristina F. / Vitamin D Status and Associations With Risk Factors for Cardiovascular Disease and Diabetes in Children Enrolled in a Medical Weight Management Program. In: Infant, Child, and Adolescent Nutrition. 2014 ; Vol. 6, No. 4. pp. 233-239.
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abstract = "Background. Studies of vitamin D status have linked low 25(OH)D levels with biomarkers of cardiovascular disease and diabetes. Obese children and adolescents are at greater risk of vitamin D deficiency as vitamin D is thought to be sequestered in adipose tissue. The objective of this analysis was to examine the associations between 25(OH)D status and risk factors for cardiovascular disease and diabetes in a population of overweight and obese children enrolled in a medical management program. Materials and Methods. A retrospective chart review was conducted of 161 children enrolled in a medical weight management program. Pearson correlation coefficient were used to evaluate associations of biochemical measurements and 25(OH)D status. Multiple regression was used to evaluate 25(OH)D levels as a predictor of risk factors for cardiovascular disease and diabetes. Results. The mean body mass index (BMI) of the population was 34 kg/m2, mean 25(OH)D levels were 21.8 ng/mL. White subjects had significantly higher 25(OH)D levels than non-whites (24.1 vs 19.2, P =.004). 25(OH)D levels were inversely related to BMI (r = −0.21, P =.03) and waist circumference (r = −0.23, P =.02). After adjustment for BMI and age, 25(OH)D was significantly associated with total cholesterol (P =.0003), triglycerides (P =.0007), homeostasis model assessment–estimated insulin resistance (HOMA-IR; P =.005) and insulin (P =.0003). The decrease in each unit of cholesterol, triglycerides, and insulin for each 1{\%} increase in log transformed 25(OH)D were 0.3, 0.65, and 0.1,1 respectively. Each 1{\%} increase in 25(OH)D levels was associated with a 0.05{\%} decrease in HOMA-IR values. Conclusion. Vitamin D status was associated with risk factors for diabetes and cardiovascular disease in an obese pediatric population.",
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T1 - Vitamin D Status and Associations With Risk Factors for Cardiovascular Disease and Diabetes in Children Enrolled in a Medical Weight Management Program

AU - Hanson, Corrine

AU - Anderson-Berry, Ann

AU - Hoskins, Shelby

AU - Lyden, Elizabeth

AU - Bilek, Laura

AU - Dolphens, Tamara

AU - Hartmann, Krystal

AU - Hawkins, Mary Jane

AU - Fernández, Cristina F.

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N2 - Background. Studies of vitamin D status have linked low 25(OH)D levels with biomarkers of cardiovascular disease and diabetes. Obese children and adolescents are at greater risk of vitamin D deficiency as vitamin D is thought to be sequestered in adipose tissue. The objective of this analysis was to examine the associations between 25(OH)D status and risk factors for cardiovascular disease and diabetes in a population of overweight and obese children enrolled in a medical management program. Materials and Methods. A retrospective chart review was conducted of 161 children enrolled in a medical weight management program. Pearson correlation coefficient were used to evaluate associations of biochemical measurements and 25(OH)D status. Multiple regression was used to evaluate 25(OH)D levels as a predictor of risk factors for cardiovascular disease and diabetes. Results. The mean body mass index (BMI) of the population was 34 kg/m2, mean 25(OH)D levels were 21.8 ng/mL. White subjects had significantly higher 25(OH)D levels than non-whites (24.1 vs 19.2, P =.004). 25(OH)D levels were inversely related to BMI (r = −0.21, P =.03) and waist circumference (r = −0.23, P =.02). After adjustment for BMI and age, 25(OH)D was significantly associated with total cholesterol (P =.0003), triglycerides (P =.0007), homeostasis model assessment–estimated insulin resistance (HOMA-IR; P =.005) and insulin (P =.0003). The decrease in each unit of cholesterol, triglycerides, and insulin for each 1% increase in log transformed 25(OH)D were 0.3, 0.65, and 0.1,1 respectively. Each 1% increase in 25(OH)D levels was associated with a 0.05% decrease in HOMA-IR values. Conclusion. Vitamin D status was associated with risk factors for diabetes and cardiovascular disease in an obese pediatric population.

AB - Background. Studies of vitamin D status have linked low 25(OH)D levels with biomarkers of cardiovascular disease and diabetes. Obese children and adolescents are at greater risk of vitamin D deficiency as vitamin D is thought to be sequestered in adipose tissue. The objective of this analysis was to examine the associations between 25(OH)D status and risk factors for cardiovascular disease and diabetes in a population of overweight and obese children enrolled in a medical management program. Materials and Methods. A retrospective chart review was conducted of 161 children enrolled in a medical weight management program. Pearson correlation coefficient were used to evaluate associations of biochemical measurements and 25(OH)D status. Multiple regression was used to evaluate 25(OH)D levels as a predictor of risk factors for cardiovascular disease and diabetes. Results. The mean body mass index (BMI) of the population was 34 kg/m2, mean 25(OH)D levels were 21.8 ng/mL. White subjects had significantly higher 25(OH)D levels than non-whites (24.1 vs 19.2, P =.004). 25(OH)D levels were inversely related to BMI (r = −0.21, P =.03) and waist circumference (r = −0.23, P =.02). After adjustment for BMI and age, 25(OH)D was significantly associated with total cholesterol (P =.0003), triglycerides (P =.0007), homeostasis model assessment–estimated insulin resistance (HOMA-IR; P =.005) and insulin (P =.0003). The decrease in each unit of cholesterol, triglycerides, and insulin for each 1% increase in log transformed 25(OH)D were 0.3, 0.65, and 0.1,1 respectively. Each 1% increase in 25(OH)D levels was associated with a 0.05% decrease in HOMA-IR values. Conclusion. Vitamin D status was associated with risk factors for diabetes and cardiovascular disease in an obese pediatric population.

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