Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention

Cedric F. Garland, Christine B. French, Leo L. Baggerly, Robert P. Heaney

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

Background: Studies indicate that intake of vitamin D in the range from 1,100 to 4,000 IU/d and a serum 25-hydroxyvitamin D concentration [25(OH)D] from 60-80 nglml may be needed to reduce cancer risk. Few community-based studies allow estimation of the dose-response relationship between oral intake of vitamin D and corresponding serum 25(OH)D in the range above 1,000 IU/d. Materials and Methods: A descriptive study of serum 25(OH)D concentration and self-reported vitamin D intake in a community-based cohort (n=3,667, mean age 51.3±13.4 y). Results: Serum 25(OH)D rose as a function of self-reported vitamin D supplement ingestion in a curvilinear fashion, with no intakes of 10,000 IU/d or lower producing 25(OH)D values above the lower-bound of the zone of potential toxicity (200 ng/ml). Unsupplemented all-source input was estimated at 3,300 IU/d. The supplemental dose ensuring that 975% of this population achieved a serum 25(OH)D of at least 40 ng/ml was 9,600 IU/d. Conclusion: Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity.

Original languageEnglish (US)
Pages (from-to)607-612
Number of pages6
JournalAnticancer Research
Volume31
Issue number2
StatePublished - Feb 1 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Garland, C. F., French, C. B., Baggerly, L. L., & Heaney, R. P. (2011). Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention. Anticancer Research, 31(2), 607-612.