Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention

Cedric F. Garland, Christine B. French, Leo L. Baggerly, Robert P. Heaney

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Background: Studies indicate that intake of vitamin D in the range from 1,100 to 4,000 IU/d and a serum 25-hydroxyvitamin D concentration [25(OH)D] from 60-80 nglml may be needed to reduce cancer risk. Few community-based studies allow estimation of the dose-response relationship between oral intake of vitamin D and corresponding serum 25(OH)D in the range above 1,000 IU/d. Materials and Methods: A descriptive study of serum 25(OH)D concentration and self-reported vitamin D intake in a community-based cohort (n=3,667, mean age 51.3±13.4 y). Results: Serum 25(OH)D rose as a function of self-reported vitamin D supplement ingestion in a curvilinear fashion, with no intakes of 10,000 IU/d or lower producing 25(OH)D values above the lower-bound of the zone of potential toxicity (200 ng/ml). Unsupplemented all-source input was estimated at 3,300 IU/d. The supplemental dose ensuring that 975% of this population achieved a serum 25(OH)D of at least 40 ng/ml was 9,600 IU/d. Conclusion: Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity.

Original languageEnglish
Pages (from-to)607-612
Number of pages6
JournalAnticancer Research
Volume31
Issue number2
StatePublished - Feb 2011

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Vitamin D
Serum
Neoplasms
25-hydroxyvitamin D
Eating
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Garland, C. F., French, C. B., Baggerly, L. L., & Heaney, R. P. (2011). Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention. Anticancer Research, 31(2), 607-612.

Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention. / Garland, Cedric F.; French, Christine B.; Baggerly, Leo L.; Heaney, Robert P.

In: Anticancer Research, Vol. 31, No. 2, 02.2011, p. 607-612.

Research output: Contribution to journalArticle

Garland, CF, French, CB, Baggerly, LL & Heaney, RP 2011, 'Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention', Anticancer Research, vol. 31, no. 2, pp. 607-612.
Garland, Cedric F. ; French, Christine B. ; Baggerly, Leo L. ; Heaney, Robert P. / Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention. In: Anticancer Research. 2011 ; Vol. 31, No. 2. pp. 607-612.
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