Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity

Andjela T. Drincic, Laura A G Armas, Eileen E. Van Diest, Robert P. Heaney

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

Vitamin D status is known to be poor in obese individuals; there is no consensus as to the reason. Cross-sectional study of the relation between serum 25-hydroxyvitamin D (25(OH)D) concentration and body size in the baseline data from unsupplemented adults entering two study cohorts in our research unit, N = 686. Regression analyses of body size variables against serum 25(OH)D concentration, using both linear and hyperbolic models. The fit to a hyperbolic model of 25(OH)D against body weight completely removed the obesity-related component of inter-individual variability in serum 25(OH)D concentration. The hyperbolic fit using total body weight was significantly better than any linear model, and specifically better than any using BMI. Dilution of ingested or cutaneously synthesized vitamin D in the large fat mass of obese patients fully explains their typically low vitamin D status. There is no evidence for sequestration of supplemental or endogenous cholecalciferol. Vitamin D replacement therapy needs to be adjusted for body size if desired serum 25(OH)D concentrations are to be achieved.

Original languageEnglish
Pages (from-to)1444-1448
Number of pages5
JournalObesity
Volume20
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Vitamin D
Body Size
Obesity
Serum
Linear Models
Body Weight
Cholecalciferol
Cohort Studies
Cross-Sectional Studies
Fats
Regression Analysis
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Drincic, A. T., Armas, L. A. G., Van Diest, E. E., & Heaney, R. P. (2012). Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity, 20(7), 1444-1448. https://doi.org/10.1038/oby.2011.404

Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. / Drincic, Andjela T.; Armas, Laura A G; Van Diest, Eileen E.; Heaney, Robert P.

In: Obesity, Vol. 20, No. 7, 07.2012, p. 1444-1448.

Research output: Contribution to journalArticle

Drincic, AT, Armas, LAG, Van Diest, EE & Heaney, RP 2012, 'Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity', Obesity, vol. 20, no. 7, pp. 1444-1448. https://doi.org/10.1038/oby.2011.404
Drincic, Andjela T. ; Armas, Laura A G ; Van Diest, Eileen E. ; Heaney, Robert P. / Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. In: Obesity. 2012 ; Vol. 20, No. 7. pp. 1444-1448.
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