Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

Joanne Kotsopoulos, Jan Lubinski, Susan L. Neuhausen, Jacek Gronwald, Henry T. Lynch, Tomasz Huzarski, Rochelle Demsky, William D. Foulkes, Leigha Senter, Susan Friedman, Peter Ainsworth, Ping Sun, Steven A. Narod

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Abstract

Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalWomen's health (London, England)
Volume11
Issue number4
DOIs
Publication statusPublished - Jul 1 2015

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kotsopoulos, J., Lubinski, J., Neuhausen, S. L., Gronwald, J., Lynch, H. T., Huzarski, T., ... Narod, S. A. (2015). Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. Women's health (London, England), 11(4), 453-459. https://doi.org/10.2217/whe.15.4