Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

Joanne Kotsopoulos, Jan Lubinski, Susan L. Neuhausen, Jacek Gronwald, Henry T. Lynch, Tomasz Huzarski, Rochelle Demsky, William D. Foulkes, Leigha Senter, Susan Friedman, Peter Ainsworth, Ping Sun, Steven A. Narod

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalWomen's health (London, England)
Volume11
Issue number4
DOIs
StatePublished - Jul 1 2015

Fingerprint

Ovariectomy
Weight Gain
Mutation
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kotsopoulos, J., Lubinski, J., Neuhausen, S. L., Gronwald, J., Lynch, H. T., Huzarski, T., ... Narod, S. A. (2015). Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. Women's health (London, England), 11(4), 453-459. https://doi.org/10.2217/whe.15.4

Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. / Kotsopoulos, Joanne; Lubinski, Jan; Neuhausen, Susan L.; Gronwald, Jacek; Lynch, Henry T.; Huzarski, Tomasz; Demsky, Rochelle; Foulkes, William D.; Senter, Leigha; Friedman, Susan; Ainsworth, Peter; Sun, Ping; Narod, Steven A.

In: Women's health (London, England), Vol. 11, No. 4, 01.07.2015, p. 453-459.

Research output: Contribution to journalArticle

Kotsopoulos, J, Lubinski, J, Neuhausen, SL, Gronwald, J, Lynch, HT, Huzarski, T, Demsky, R, Foulkes, WD, Senter, L, Friedman, S, Ainsworth, P, Sun, P & Narod, SA 2015, 'Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation', Women's health (London, England), vol. 11, no. 4, pp. 453-459. https://doi.org/10.2217/whe.15.4
Kotsopoulos J, Lubinski J, Neuhausen SL, Gronwald J, Lynch HT, Huzarski T et al. Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. Women's health (London, England). 2015 Jul 1;11(4):453-459. https://doi.org/10.2217/whe.15.4
Kotsopoulos, Joanne ; Lubinski, Jan ; Neuhausen, Susan L. ; Gronwald, Jacek ; Lynch, Henry T. ; Huzarski, Tomasz ; Demsky, Rochelle ; Foulkes, William D. ; Senter, Leigha ; Friedman, Susan ; Ainsworth, Peter ; Sun, Ping ; Narod, Steven A. / Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. In: Women's health (London, England). 2015 ; Vol. 11, No. 4. pp. 453-459.
@article{0c57a45857c24ac4a9b02ff3d9769d77,
title = "Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation",
abstract = "Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.",
author = "Joanne Kotsopoulos and Jan Lubinski and Neuhausen, {Susan L.} and Jacek Gronwald and Lynch, {Henry T.} and Tomasz Huzarski and Rochelle Demsky and Foulkes, {William D.} and Leigha Senter and Susan Friedman and Peter Ainsworth and Ping Sun and Narod, {Steven A.}",
year = "2015",
month = "7",
day = "1",
doi = "10.2217/whe.15.4",
language = "English",
volume = "11",
pages = "453--459",
journal = "Women's health (London, England)",
issn = "1745-5065",
publisher = "Future Medicine Ltd.",
number = "4",

}

TY - JOUR

T1 - Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

AU - Kotsopoulos, Joanne

AU - Lubinski, Jan

AU - Neuhausen, Susan L.

AU - Gronwald, Jacek

AU - Lynch, Henry T.

AU - Huzarski, Tomasz

AU - Demsky, Rochelle

AU - Foulkes, William D.

AU - Senter, Leigha

AU - Friedman, Susan

AU - Ainsworth, Peter

AU - Sun, Ping

AU - Narod, Steven A.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

AB - Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

UR - http://www.scopus.com/inward/record.url?scp=84939813531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939813531&partnerID=8YFLogxK

U2 - 10.2217/whe.15.4

DO - 10.2217/whe.15.4

M3 - Article

C2 - 26258912

AN - SCOPUS:84939813531

VL - 11

SP - 453

EP - 459

JO - Women's health (London, England)

JF - Women's health (London, England)

SN - 1745-5065

IS - 4

ER -