Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

Joanne Kotsopoulos; Jan Lubinski; Susan L. Neuhausen; Jacek Gronwald; Henry T. Lynch; Tomasz Huzarski; Rochelle Demsky; William D. Foulkes; Leigha Senter; Susan Friedman; Peter Ainsworth; Ping Sun; Steven A. Narod

doi:10.2217/whe.15.4

Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

Joanne Kotsopoulos, Jan Lubinski, Susan L. Neuhausen, Jacek Gronwald, Henry T. Lynch, Tomasz Huzarski, Rochelle Demsky, William D. Foulkes, Leigha Senter, Susan Friedman, Peter Ainsworth, Ping Sun, Steven A. Narod

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

Original language	English (US)
Pages (from-to)	453-459
Number of pages	7
Journal	Women's Health
Volume	11
Issue number	4
DOIs	https://doi.org/10.2217/whe.15.4
State	Published - Jul 1 2015

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.2217/whe.15.4

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title = "Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation",

abstract = "Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.",

author = "Joanne Kotsopoulos and Jan Lubinski and Neuhausen, {Susan L.} and Jacek Gronwald and Lynch, {Henry T.} and Tomasz Huzarski and Rochelle Demsky and Foulkes, {William D.} and Leigha Senter and Susan Friedman and Peter Ainsworth and Ping Sun and Narod, {Steven A.}",

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year = "2015",

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doi = "10.2217/whe.15.4",

language = "English (US)",

volume = "11",

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TY - JOUR

T1 - Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

AU - Kotsopoulos, Joanne

AU - Lubinski, Jan

AU - Neuhausen, Susan L.

AU - Gronwald, Jacek

AU - Lynch, Henry T.

AU - Huzarski, Tomasz

AU - Demsky, Rochelle

AU - Foulkes, William D.

AU - Senter, Leigha

AU - Friedman, Susan

AU - Ainsworth, Peter

AU - Sun, Ping

AU - Narod, Steven A.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

AB - Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.

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ER -

Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation

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