Abstract
Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.
| Original language | English |
|---|---|
| Pages (from-to) | 453-459 |
| Number of pages | 7 |
| Journal | Women's health (London, England) |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2015 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation. / Kotsopoulos, Joanne; Lubinski, Jan; Neuhausen, Susan L.; Gronwald, Jacek; Lynch, Henry T.; Huzarski, Tomasz; Demsky, Rochelle; Foulkes, William D.; Senter, Leigha; Friedman, Susan; Ainsworth, Peter; Sun, Ping; Narod, Steven A.
In: Women's health (London, England), Vol. 11, No. 4, 01.07.2015, p. 453-459.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Weight gain after oophorectomy among women with a BRCA1 or BRCA2 mutation
AU - Kotsopoulos, Joanne
AU - Lubinski, Jan
AU - Neuhausen, Susan L.
AU - Gronwald, Jacek
AU - Lynch, Henry T.
AU - Huzarski, Tomasz
AU - Demsky, Rochelle
AU - Foulkes, William D.
AU - Senter, Leigha
AU - Friedman, Susan
AU - Ainsworth, Peter
AU - Sun, Ping
AU - Narod, Steven A.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.
AB - Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.
UR - http://www.scopus.com/inward/record.url?scp=84939813531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939813531&partnerID=8YFLogxK
U2 - 10.2217/whe.15.4
DO - 10.2217/whe.15.4
M3 - Article
C2 - 26258912
AN - SCOPUS:84939813531
VL - 11
SP - 453
EP - 459
JO - Women's health (London, England)
JF - Women's health (London, England)
SN - 1745-5065
IS - 4
ER -