Xeroderma Pigmentosum, Malignant Melanoma, and Congenital Ichthyosis: A Family Study

Henry T. Lynch, D. E. Anderson, A. J. Krush

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A medicogenetic and pathologic study was made of a family wherein five of seven siblings manifested xeroderma pigmentosum (XDP); four showed congenital ichthyosis in association with XDP, and of these two had the complication of malignant melanoma. One sibling showed only XDP. Another sibling was clinically free of XDP, but showed histologic evidence of this disease and manifested unequivocal evidence of congenital ichthyosis. Only one other example of the association of XDP and congenital ichthyosis was found. This family is of further interest because of the occurrence of malignant melanoma in two of these siblings; review of the world literature showed that malignant melanoma is an important complication of XDP though this point is rarely emphasized.

Original languageEnglish
Pages (from-to)625-635
Number of pages11
JournalArchives of Dermatology
Volume96
Issue number6
DOIs
StatePublished - 1967
Externally publishedYes

Fingerprint

Ichthyosis
Xeroderma Pigmentosum
Melanoma

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Xeroderma Pigmentosum, Malignant Melanoma, and Congenital Ichthyosis : A Family Study. / Lynch, Henry T.; Anderson, D. E.; Krush, A. J.

In: Archives of Dermatology, Vol. 96, No. 6, 1967, p. 625-635.

Research output: Contribution to journalArticle

@article{93d5ff0268d9484dbdeff188cad297f4,
title = "Xeroderma Pigmentosum, Malignant Melanoma, and Congenital Ichthyosis: A Family Study",
abstract = "A medicogenetic and pathologic study was made of a family wherein five of seven siblings manifested xeroderma pigmentosum (XDP); four showed congenital ichthyosis in association with XDP, and of these two had the complication of malignant melanoma. One sibling showed only XDP. Another sibling was clinically free of XDP, but showed histologic evidence of this disease and manifested unequivocal evidence of congenital ichthyosis. Only one other example of the association of XDP and congenital ichthyosis was found. This family is of further interest because of the occurrence of malignant melanoma in two of these siblings; review of the world literature showed that malignant melanoma is an important complication of XDP though this point is rarely emphasized.",
author = "Lynch, {Henry T.} and Anderson, {D. E.} and Krush, {A. J.}",
year = "1967",
doi = "10.1001/archderm.1967.01610060019002",
language = "English",
volume = "96",
pages = "625--635",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "6",

}

TY - JOUR

T1 - Xeroderma Pigmentosum, Malignant Melanoma, and Congenital Ichthyosis

T2 - A Family Study

AU - Lynch, Henry T.

AU - Anderson, D. E.

AU - Krush, A. J.

PY - 1967

Y1 - 1967

N2 - A medicogenetic and pathologic study was made of a family wherein five of seven siblings manifested xeroderma pigmentosum (XDP); four showed congenital ichthyosis in association with XDP, and of these two had the complication of malignant melanoma. One sibling showed only XDP. Another sibling was clinically free of XDP, but showed histologic evidence of this disease and manifested unequivocal evidence of congenital ichthyosis. Only one other example of the association of XDP and congenital ichthyosis was found. This family is of further interest because of the occurrence of malignant melanoma in two of these siblings; review of the world literature showed that malignant melanoma is an important complication of XDP though this point is rarely emphasized.

AB - A medicogenetic and pathologic study was made of a family wherein five of seven siblings manifested xeroderma pigmentosum (XDP); four showed congenital ichthyosis in association with XDP, and of these two had the complication of malignant melanoma. One sibling showed only XDP. Another sibling was clinically free of XDP, but showed histologic evidence of this disease and manifested unequivocal evidence of congenital ichthyosis. Only one other example of the association of XDP and congenital ichthyosis was found. This family is of further interest because of the occurrence of malignant melanoma in two of these siblings; review of the world literature showed that malignant melanoma is an important complication of XDP though this point is rarely emphasized.

UR - http://www.scopus.com/inward/record.url?scp=0014174189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014174189&partnerID=8YFLogxK

U2 - 10.1001/archderm.1967.01610060019002

DO - 10.1001/archderm.1967.01610060019002

M3 - Article

C2 - 6075779

AN - SCOPUS:0014174189

VL - 96

SP - 625

EP - 635

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 6

ER -