ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons

An Jing Ren, Kai Wang, Huan Zhang, Anjun Liu, Xianhua Ma, Qing Liang, Dongmei Cao, John N. Wood, David Z. He, Yu Qiang Ding, Wen Jun Yuan, Zhifang Xie, Weiping J. Zhang

Research output: Contribution to journalArticle

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Abstract

In mammals, pain sensation is initiated by the detection of noxious stimuli through specialized transduction ion channels and receptors in nociceptive sensory neurons. Transient receptor potential (TRP) channels are the key sensory transducers that confer nociceptors distinct sensory modalities. However, the regulatory mechanisms about their expression are poorly defined. Here we show that the zinc-finger protein ZBTB20 regulates TRP channels expression in nociceptors. ZBTB20 is highly expressed in nociceptive sensory neurons of dorsal root ganglia. Disruption of ZBTB20 in nociceptors led to a marked decrease in the expression levels of TRPV1, TRPA1 and TRPM8 and the response of calcium flux and whole-cell currents evoked by their respective specific agonists. Phenotypically, the mice lacking ZBTB20 specifically in nociceptors showed a defect in nociception and pain sensation in response to thermal, mechanical and inflammatory stimulation. Our findings point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channels expression in nociceptors.

Original languageEnglish
Article number4984
JournalNature Communications
Volume5
DOIs
StatePublished - 2014

Fingerprint

Transient Receptor Potential Channels
Nociceptors
Nociception
pain
Sensory Receptor Cells
neurons
Neurons
Pain
Mammals
Ion Channels
mammals
Zinc
Transducers
regulators
stimulation
stimuli
Fluxes
Calcium
mice
calcium

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)
  • Medicine(all)

Cite this

ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. / Ren, An Jing; Wang, Kai; Zhang, Huan; Liu, Anjun; Ma, Xianhua; Liang, Qing; Cao, Dongmei; Wood, John N.; He, David Z.; Ding, Yu Qiang; Yuan, Wen Jun; Xie, Zhifang; Zhang, Weiping J.

In: Nature Communications, Vol. 5, 4984, 2014.

Research output: Contribution to journalArticle

Ren, AJ, Wang, K, Zhang, H, Liu, A, Ma, X, Liang, Q, Cao, D, Wood, JN, He, DZ, Ding, YQ, Yuan, WJ, Xie, Z & Zhang, WJ 2014, 'ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons', Nature Communications, vol. 5, 4984. https://doi.org/10.1038/ncomms5984
Ren, An Jing ; Wang, Kai ; Zhang, Huan ; Liu, Anjun ; Ma, Xianhua ; Liang, Qing ; Cao, Dongmei ; Wood, John N. ; He, David Z. ; Ding, Yu Qiang ; Yuan, Wen Jun ; Xie, Zhifang ; Zhang, Weiping J. / ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. In: Nature Communications. 2014 ; Vol. 5.
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AU - Zhang, Huan

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AU - Ma, Xianhua

AU - Liang, Qing

AU - Cao, Dongmei

AU - Wood, John N.

AU - He, David Z.

AU - Ding, Yu Qiang

AU - Yuan, Wen Jun

AU - Xie, Zhifang

AU - Zhang, Weiping J.

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