Zn2+ inhibits the anion transport activity of Band 3 by binding to its cytoplasmic tail

Yaping Tu, H. Xu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Zn2+ can induce a conformational change of Band 3 with concomitant inhibition of its anion transport activity of human erythrocyte membrane vesicles only from the cytoplasmic side. The Zn2+ inhibition exhibits a dose-dependent manner with an apparent half maximal concentration of 50 μM ZnCl2 and can be reversed by 0.5 mM EDTA, but not by 1 mM dithiothreitol. The Zn2+ effect is specific and no similar inhibitory action could be observed by other divalent cations (Cu2+, Mn2+, Mg2+ or Sr2+).

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalBioscience Reports
Volume14
Issue number4
DOIs
StatePublished - Aug 1994
Externally publishedYes

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Cytoplasmic Vesicles
Dithiothreitol
Divalent Cations
Erythrocyte Membrane
Human Activities
Edetic Acid
Anions
Membranes

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zn2+ inhibits the anion transport activity of Band 3 by binding to its cytoplasmic tail. / Tu, Yaping; Xu, H.

In: Bioscience Reports, Vol. 14, No. 4, 08.1994, p. 159-169.

Research output: Contribution to journalArticle

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