Zn2+ inhibits the anion transport activity of Band 3 by binding to its cytoplasmic tail

Y. P. Tu, H. Xu

Research output: Contribution to journalArticle

10 Scopus citations


Zn2+ can induce a conformational change of Band 3 with concomitant inhibition of its anion transport activity of human erythrocyte membrane vesicles only from the cytoplasmic side. The Zn2+ inhibition exhibits a dose-dependent manner with an apparent half maximal concentration of 50 μM ZnCl2 and can be reversed by 0.5 mM EDTA, but not by 1 mM dithiothreitol. The Zn2+ effect is specific and no similar inhibitory action could be observed by other divalent cations (Cu2+, Mn2+, Mg2+ or Sr2+).

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalBioscience Reports
Issue number4
StatePublished - Aug 1 1994


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this